AustralieFrV1, Main, Exploration, bibRecord, 001C10

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

Identifieur interne : 001C10 ( Main/Exploration ); précédent : 001C09; suivant : 001C11

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

Auteurs : Eva C. Boritsch [France] ; Varun Khanna [France] ; Alexandre Pawlik [France] ; Nadine Honoré [France] ; Victor H. Navas [France] ; Laurence Ma [France] ; Christiane Bouchier [France] ; Torsten Seemann [Australie] ; Philip Supply [France] ; Timothy P. Stinear [Australie] ; Roland Brosch [France]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.

RBID : PMC:5024641

Abstract

Significance

Whereas most of the more than 130 described mycobacterial species are harmless saprophytes, Mycobacterium tuberculosis, the human tuberculosis-causing agent, represents one of the deadliest bacterial pathogens in the history of humankind. To explore the mechanisms behind this spectacular evolutionary trajectory toward pathogenicity, we have experimentally investigated the faculty of different tuberculosis-causing mycobacteria in conducting horizontal gene transfer (HGT). Our studies identified unique chromosomal DNA transfer between strains of the Mycobacterium canettii clade, which resemble most closely the putative common ancestor of the M. tuberculosis complex. This outstanding feature suggests that during the evolution of M. tuberculosis, HGT might have represented the major mechanism for acquisition of genes that helped these mycobacteria to increasingly resist host defenses and become major pathogens.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024641

DOI: 10.1073/pnas.1604921113
PubMed: 27528665
PubMed Central: 5024641

Affiliations:

Australie, France

Le document en format XML

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Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

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Abstract

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